Fujita et al. 2010¶
Model by Fujita et al 2010 as one of the proposed benchmark models provided by Hass et al. 2019. The model represents epidermal growth factor (EGF)-dependent Akt pathway. Data from [Fig. 1b] with a corresponding EGF step input from [Fig. 1a] in Fujita et al. 2010 was used for estimation and Global Sensitity Analysis of 12 parameters. We performed parameter estimation starting from the model parameters provided in the publication, using a search space 5 order of magnitude above and below for each parameter.
Reactions chosen for parameter estimation and Global Sensitivity Analysis
EGFR + EGF <=> EGF_EGFR
pEGFR + Akt <=> pEGFR_Akt
pEGFR_Akt -> pEGFR + pAkt
pEGFR -> null
pAkt + S6 <=> pAkt_S6
pAkt_S6 -> pAkt + pS6
pAkt -> Akt
pS6 -> S6
EGF_EGFR -> pEGFR
EGFR -> null
Model Repository
https://github.com/jpgsantos/Model_Fujita_2010